OMPHALITIS

OMPHALITIS

 Def : Infection of the umbilicus and/or surrounding tissues.
Incidence : approximately 1 in 1,000 infants in developed countries where aseptic delivery and hygienic dry cord care are practiced.

The risk factors associated with the development of omphalitis include:

• prolonged rupture of membranes
• maternal infection
• nonsterile delivery practices
• home delivery
• umbilical catheterization
• low birth weight
• improper cord care or cultural practices of cord care (such as application of cow dung, charcoal dust, or products such as cooking oil and baby powder to the cord stump, and lotus births)
• delayed cord separation
• immunologic conditions such as defects in leukocyte adhesion, neutrophil or natural killer lymphocyte function, and interferon production.

Clinical features:
Mild discharge from the umbilical stump in the absence of inflammatory signs may be a normal occurrence, even when accompanied by some odor.

Unhealthy, discolored, and craggy-appearing umbilical stump; purulent drainage; periumbilical erythema; and induration.

Umbilical stump bleeding may occur with omphalitis because the infection delays thrombosis of the umbilical vessels.

Systemic signs, including lethargy, fever, irritability, temperature instability and poor feeding are suggestive of more severe infection or complication. The most common complication of omphalitis is sepsis.

Other complications include septic umbilical arteritis, portal vein thrombosis, liver abscess, peritonitis, intestinal gangrene, small bowel evisceration, necrotizing fasciitis, and death (Mortality rate is estimated between 7 and 15 percent)
 

Omphalitis is a polymicrobial infection. Historically, the predominant pathogens included Staphylococcus aureus, Streptococcus pyogenes, and Gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. However, with the routine use of antistaphylococcal cord care regimens, Gram-negative infections of the umbilicus have increased . In addition, anaerobic bacteria such as Bacteroides fragilis, Clostridium perfringens, and Clostridium tetani can contribute to umbilical infections, especially in infants born to mothers with chorioamnionitis . In these infants, foul smelling umbilical drainage is a typical finding.

Periumbilical necrotizing fasciitis in the newborn

 Periumbilical necrotizing fasciitis in the newborn

Neonatal necrotizing fasciitis is a rare complication of omphalitis.

Necrotizing fasciitis starts initially as periumbilical cellulitis and rapidly spreads to the subcutaneous tissues, with the overlying skin appearing edematous with purplish blue discoloration.

Necrotizing fasciitis may also present with bullae, crepitus and peau d’orange appearance.

Necrotizing fasciitis should be recognized early and treated aggressively by debridement, broad-spectrum antibiotics, and supportive care.

In addition to debridement of the involved abdominal wall, it is important to resect the umbilical vein, both umbilical arteries, and any urachal remnant that is present, as these may be involved in the necrotizing infection (even if they look normal).

Reported mortality rates are as high as 60 to 85 percent.

References:

1. Cilley R. Disorders of the umbilicus. In: Pediatric Surgery, Grosfeld J, O'Neill J, Coran A, Fonkalsrud E (Eds), Mosby Inc., Philadelphia 2006.
2. Pomeranz A. Anomalies, abnormalities, and care of the umbilicus. Pediatr Clin North Am 2004; 51:819.

 

Funisitis

 

Funisitis

Funisitis is inflammation of the connective tissue of the umbilical cord that occurs with chorioamnionitis. It involves only the external cord surface and Wharton's jelly. It has no involvement of the vessels.

It does not involve the umbilical stump, which would be seen in omphalitis.

Necrotizing funisitis occurs with long-standing infection and is characterized by inflammatory debris and calcification of umbilical cord tissues.

Infants with funisitis can be born healthy, but should be treated with broad-spectrum antibiotics (similar to the regimen used for omphalitis) for a minimum of seven days of therapy.

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