OMPHALOMESENTERIC (VITELLINE) REMNANT

 

OMPHALOMESENTERIC (VITELLINE) REMNANT

Partial or complete failure of involution of the omphalomesenteric duct can lead to a spectrum of anomalies in the newborn infant due to varying degrees and location of duct patency:

A.   An umbilical cyst containing intestinal tissue.

B.   Umbilical sinus with a band.

C.   A persistent omphalomesenteric duct at the umbilicus with no intestinal connection results in an umbilical polyp.

D.   Patent mid-duct with closure at both the umbilical and ileal ends of the omphalomesenteric duct results in an omphalomesenteric duct cyst. Because the two ends are fixed, this can lead to small bowel obstruction if loops of bowel twist around the cyst.

E.   Persistent tissue at the ileum, with no connection to the umbilicus results in Meckel's diverticulum.

F.   Complete patency results in the omphalomesenteric duct directly connecting the umbilicus to the terminal ileum. This can lead to intermittent drainage from the umbilicus " omphalomesenteric fistula". These infants will often appear to have a "stoma" in the umbilicus after cord separation.

G.  Persistent fibrous cord (band)  between the umbilicus and the ileum, which can lead to small bowel obstruction.

Refeeding Syndrome

Refeeding syndrome occurs in response to reintroduction of nutrition (whether enterally or parenterally) in the malnourished patient.

Rapid electrolyte and fluid Intracellular shifts in response to the surge of insulin brought on by the presence of nutrients which can lead to numerous medical complications and may progress to life-threatening outcomes, including Coma heart failure, and sudden death.

The hallmark biochemical feature of refeeding syndrome is hypophosphatemia. However, the syndrome is complex and may also feature abnormal sodium and fluid balance; changes in glucose, protein, and fat metabolism; thiamine deficiency; hypokalaemia; and hypomagnesaemia.

Pathogenesis (Howdoes refeeding syndrome develop?) 

Clinical Signs and Symptoms of Refeeding Syndrome

Patient populations at risk for refeeding syndrome  

Prevention and management of refeeding syndrome